Journal
DIABETES
Volume 63, Issue 12, Pages 4089-4099Publisher
AMER DIABETES ASSOC
DOI: 10.2337/db14-0746
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Funding
- Institute for Translational Sciences at the University of Texas Medical Branch (Galveston, TX)
- National Center for Advancing Translational Sciences [UL1TR000071]
- National Institutes of Health
- American Diabetes Association [1-14-TS-35]
- Shriners Hospitals for Children [84090, 85310]
- John Sealy Memorial Endowment Fund for Biomedical Research [66992]
- Claude D. Pepper Older Americans Independence Center [P30 AG024832]
- Sealy Center on Aging
- Onassis Foundation
- Swedish Research Council [2010-3281, 2012-1652]
- Knut and Alice Wallenberg Foundation
- Sahlgrenska University Hospital (LUA-ALF)
- European Union [HEALTH-F2-2011-278373]
- Inga Britt and Arne Lundgren Foundation
- Soderberg Foundation
- King Gustaf V and Queen Victoria Freemason Foundation
- Canadian Institutes of Health Research
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Brown adipose tissue (BAT) has attracted scientific interest as an antidiabetic tissue owing to its ability to dissipate energy as heat. Despite a plethora of data concerning the role of BAT in glucose metabolism in rodents, the role of BAT (if any) in glucose metabolism in humans remains unclear. To investigate whether BAT activation alters whole-body glucose homeostasis and insulin sensitivity in humans, we studied seven BAT-positive (BAT(+)) men and five BAT-negative (BAT(-)) men under thermoneutral conditions and after prolonged (5-8 h) cold exposure (CE). The two groups were similar in age, BMI, and adiposity. CE significantly increased resting energy expenditure, whole-body glucose disposal, plasma glucose oxidation, and insulin sensitivity in the BAT+ group only. These results demonstrate a physiologically significant role of BAT in whole-body energy expenditure, glucose homeostasis, and insulin sensitivity in humans, and support the notion that BAT may function as an antidiabetic tissue in humans.
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