Journal
DIABETES
Volume 62, Issue 11, Pages 3951-3956Publisher
AMER DIABETES ASSOC
DOI: 10.2337/db13-0215
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Funding
- Swedish Research Council
- Lund University Diabetes Centre
- Knut and Alice Wallenberg Foundation
- European Union 7th Framework Programme: DIAPREPP [202013]
- Swedish Diabetes Association Research Fund
- Academy of Finland
- Centre of Excellence in Molecular Systems Immunology and Physiology Research [2012-2017, 250114]
- Childhood Diabetes Foundation
- Skane County Council for Research and Development
- UMAS Funds
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Children developing type 1 diabetes may have risk markers already in their umbilical cord blood. It is hypothesized that the risk for type 1 diabetes at an early age may be increased by a pathogenic pregnancy and be reflected in altered cord-blood composition. This study used metabolomics to test if the cord-blood lipidome was affected in children diagnosed with type 1 diabetes before 8 years of age. The present case-control study of 76 index children diagnosed with type 1 diabetes before 8 years of age and 76 healthy control subjects matched for HLA risk, sex, and date of birth, as well as the mother's age and gestational age, revealed that cord-blood phosphatidylcholines and phosphatidylethanolamines were significantly decreased in children diagnosed with type 1 diabetes before 4 years of age. Reduced levels of triglycerides correlated to gestational age in index and control children and to age at diagnosis only in the index children. Finally, gestational infection during the first trimester was associated with lower cord-blood total lysophosphatidylcholines in index and control children. In conclusion, metabolomics of umbilical cord blood may identify children at increased risk for type 1 diabetes. Low phospholipid levels at birth may represent key mediators of the immune system and contribute to early induction of islet autoimmunity.
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