Journal
DIABETES
Volume 62, Issue 2, Pages 424-434Publisher
AMER DIABETES ASSOC
DOI: 10.2337/db11-1718
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Funding
- Department of Veterans Affairs
- American Heart Association [10GRNT3650024]
- Atlantic Philanthropies
- American Diabetes Association [1-09-IG-01]
- John A. Hartford Foundation
- Association of Specialty Professors
- Vanderbilt Diabetes Research and Training Center Pilot and Feasibility Program [DK20593]
- Vanderbilt Digestive Diseases Research Center Pilot and Feasibility Program [DK058404]
- Canadian Institutes of Health Research
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Pathway-selective insulin resistance where insulin fails to suppress hepatic glucose production but promotes liver fat storage may underlie glucose and lipid abnormalities after menopause. We tested the mechanisms by which estrogen treatment may alter the impact of a high-fat diet (HED) when given at the time of ovariectomy (OVX) in mice. Female C57BL/6J mice underwent sham operation, OVX, or OVX with estradiol (E2) treatment and were fed an HFD. Hyperinsulinemic-euglycemic clamps were used to assess insulin sensitivity, tracer incorporation into hepatic lipids, and liver triglyceride export. OVX mice had increased adiposity that was prevented with E2 at the time of OVX. E2 treatment increased insulin sensitivity with OVX and HFD. In sham and OVX mice, BID feeding induced fatty liver, and insulin reduced hepatic apoB100 and liver triglyceride export. E2 treatment reduced liver lipid deposition and prevented the decrease in liver triglyceride export during hyperinsulinemia. In mice lacking the liver estrogen receptor a, E2 after OVX limited adiposity but failed to improve insulin sensitivity, to limit liver lipid deposition, and to prevent insulin suppression of liver triglyceride export. In conclusion, estrogen treatment may reverse aspects of pathway-selective insulin resistance by promoting insulin action on glucose metabolism but limiting hepatic lipid deposition. Diabetes 62:424-434, 2013
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