Journal
DIABETES
Volume 60, Issue 12, Pages 3159-3168Publisher
AMER DIABETES ASSOC
DOI: 10.2337/db10-1805
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Funding
- National Research Foundation (NRF) [KOSEF 2009-0079485]
- Ministry of Education, Science, and Technology (MEST)
- University of Ulsan
- Science Research Center (Center for Food & Nutritional Genomics) of the NRF of Korea [2010-0001886]
- Ministry of Education, Culture, Sport, Science, and Technology of Japan [22228001]
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OBJECTIVE-Inflammation is an important factor in the development of insulin resistance, type 2 diabetes, and fatty liver disease. As a member of the tumor necrosis factor receptor superfamily (TNFRSF9) expressed on immune cells, 4-1BB/CD137 provides a bidirectional inflammatory signal through binding to its ligand 4-1BBL. Both 4-1BB and 4-1BBL have been shown to play an important role in the pathogenesis of various inflammatory diseases. RESEARCH DESIGN AND METHODS-Eight-week-old male 4-1BB-deficient and wild-type (WT) mice were fed a high-fat diet (HFD) or a regular diet for 9 weeks. RESULTS-We demonstrate that 4-1BB deficiency protects against HFD-induced obesity, glucose intolerance, and fatty liver disease. The 4-1BB-deficient mice fed an HFD showed less body weight gain, adiposity, adipose infiltration of macrophages/T cells, and tissue levels of inflammatory cytokines (e.g., TNF-alpha, interleukin-6, and monocyte chemoattractant protein-1 [MCP-1]) compared with HFD-fed control mice. HFD-induced glucose intolerance/insulin resistance and fatty liver were also markedly attenuated in the 4-1BB-deficient mice. CONCLUSIONS-These findings suggest that 4-1BB and 4-1BBL may be useful therapeutic targets for combating obesity-induced inflammation and metabolic disorders. Diabetes 60:3159-3168, 2011
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