Journal
DEVELOPMENTAL PSYCHOBIOLOGY
Volume 54, Issue 6, Pages 578-589Publisher
WILEY
DOI: 10.1002/dev.20546
Keywords
neurotrophins; SVZ; neurogenesis; BDNF; TrkB; p75NTR; olfactory bulb
Categories
Funding
- Sackler Institute
- New York Community Trust
- Irma T. Hirschl/Monique Weill-Caulier Trust
- International Mental Health Research Organization
- Burroughs Wellcome Foundation
- Pritzker Consortiun
- NARSAD
- National Institutes of Health [MH060478, NS052819, MH088814, MH090237]
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The sensory processing of odorants is a dynamic process that requires plasticity at multiple levels. In the olfactory bulb (OB), inhibitory interneurons undergo lifelong replacement through a process known as adult neurogenesis. These newly born cells are incorporated in a learning-dependent fashion, a process which has led some to suggest this as a primary mechanism through which the OB retains a high degree of plasticity throughout life. A continued focus of researchers in this field has been to understand the molecular mechanisms controlling adult subventricular zone (SVZ) neurogenesis and the innate functional role of these cells. Brain-derived neurotrophic factor (BDNF) has been identified as a strong candidate molecule regulating adult OB neurogenesis. We review what is known regarding the functional role of newly born cells, highlight the role of BDNF in this process, and describe preliminary findings from our lab implicating BDNF in the process of selecting of newly born cells for survival. (c) 2011 Wiley Periodicals,Inc. Dev Psychobiol 54: 578589, 2012..
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