Journal
DEVELOPMENTAL PSYCHOBIOLOGY
Volume 52, Issue 4, Pages 331-342Publisher
WILEY
DOI: 10.1002/dev.20424
Keywords
epigenetic; psychiatric disorders; development; histone; methylation
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Funding
- NIDA [1K99DA026503-01, 1RO3 DA022262-01]
- Michael Smith Foundation for Health Research (MSFHR)
- CIHR
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Epigenetics commonly refers to the developmental process by which cellular traits are established and inherited without a change in DNA sequence. These mechanisms of cellular memory also orchestrate gene expression in the adult brain and recent evidence suggests that the epigenome' represents a critical interface between environmental signals, activation, repression and maintenance of genomic responses, and persistent behavior. We here review the current state of knowledge regarding the contribution of the epigenome toward the development of psychiatric disorders. (C) 2010 Wiley Periodicals, Inc. Dev Psychobiol 52: 331-342, 2010.
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