Journal
DEVELOPMENTAL NEUROSCIENCE
Volume 33, Issue 1, Pages 1-13Publisher
KARGER
DOI: 10.1159/000321585
Keywords
Tailless; Tlx; Nuclear receptor; Neural stem cell; PTEN; Atrophin; Lysine-specific histone demethylase 1; Histone deacetylase; Proliferation; Differentiation
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Funding
- NIH [5R01NS050365]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS050365] Funding Source: NIH RePORTER
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Drosophila Tailless (Tll) and its vertebrate homologue Tlx are conserved orphan nuclear receptors specifically expressed in the eye and the forebrain. Tll and Tlx act primarily as transcriptional repressors through their interactions with transcriptional corepressors, Atrophin family proteins, and histone-tail/chromatin-modifying factors such as lysine-specific histone demethylase 1 and histone deacetylases. The functional importance of Tll and Tlx is made apparent by the recent discovery that they are expressed in neural stem cells (NSCs) and are required for self-renewal of these cells in both Drosophila and the mouse. This review provides a snapshot of current knowledge about Tll and Tlx and their transcriptional network, which maintains NSCs in developing and adult animals. Copyright (C) 2010 S. Karger AG, Basel
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