Journal
DEVELOPMENTAL NEUROPSYCHOLOGY
Volume 39, Issue 3, Pages 226-232Publisher
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/87565641.2013.874428
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Funding
- National Center for Research Resources (NCRR), a part of the National Institutes of Health (NIH) [UL1RR024979]
- NIH [P01 HL046925]
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Examine the relationship between brain structure and cognition in preterm children randomly assigned to a liberal red blood cell (RBC) transfusion strategy as neonates. Intelligence, achievement, and neuropsychological measures were assessed and structural imaging was obtained (n = 26; 38% male). Global brain volumes were related to cognitive outcome. Additionally, females performed lower on verbal fluency; lower performance was related to temporal white matter volume. Findings provide possible evidence of the adverse effect of a liberal RBC transfusion strategy in which females had decreased temporal lobe white matter directly related to poor verbal fluency.
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