Journal
DEVELOPMENTAL NEUROBIOLOGY
Volume 72, Issue 6, Pages 766-776Publisher
WILEY-BLACKWELL
DOI: 10.1002/dneu.20981
Keywords
nerve growth factor; p75NTR; cell cycle; proliferation; astrocyte
Categories
Funding
- NIH [NS045556]
- New Jersey Commission for Brain Injury Research
Ask authors/readers for more resources
Neurotrophins can influence multiple cellular functions depending on the cellular context and the specific receptors they interact with. These neurotrophic factors have been extensively studied for their ability to support neuronal survival via Trk receptors and to induce apoptosis via the p75NTR. However, the p75NTR is also detected on cell populations that do not undergo apoptosis in response to neurotrophins. In particular, the authors have detected p75NTR expression on astrocytes during development and after seizure-induced injury. In this study, the authors investigated the role of Nerve growth factor (NGF) in regulating astrocyte proliferation and in influencing specific aspects of the cell cycle. The authors have demonstrated that NGF prevents the induction of cyclins and their association with specific cyclin-dependent kinases, and thereby prevents progression through the G1 phase of the cell cycle. Since the authors have previously shown that p75NTR but not TrkA, is expressed in astrocytes, these data suggest that activation of p75NTR promotes withdrawal of astrocytes from the cell cycle, which may have important consequences during development and after injury. (C) 2011 Wiley Periodicals, Inc. Develop Neurobiol 72: 766776, 2012
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available