Journal
DEVELOPMENTAL NEUROBIOLOGY
Volume 72, Issue 1, Pages 134-144Publisher
WILEY
DOI: 10.1002/dneu.20916
Keywords
synaptic vesicle; exocytosis; endocytosis; a-synuclein; SNARE complex
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Funding
- Marie Curie Excellence grant [MEXT-CT-2006-042267]
- FWO [G074709, G094011, G095511]
- Research Fund KU Leuven
- Flemish Government
- Francqui Foundation
- Instutute for the Promotion of Innovation through Science and Technology in Flanders (IWT-Vlaanderen)
- ERC [260678]
- European Research Council (ERC) [260678] Funding Source: European Research Council (ERC)
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Presynaptic terminals maintain neurotransmitter release during repeated rounds of stimulation using local recycling of synaptic vesicles (SV). During each SV cycle, protein complex assembly and disassembly results in accumulation of inactive (unfolded) protein intermediates that may render synaptic terminals vulnerable to activity-dependent degeneration. SV trafficking is affected in many neurodegenerative conditions including Alzheimer' and Parkinson's disease (PD) suggesting that alteration of this process might be an important aspect of disease pathogenesis. This article reviews our current understanding for a role of causative PD genes in the SV cycle and speculates on the potential role of aberrant SV trafficking in the neurodegenerative cascade of PD. (c) 2011 Wiley Periodicals, Inc. Develop Neurobiol 72: 134144, 2012
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