Journal
DEVELOPMENTAL NEUROBIOLOGY
Volume 71, Issue 12, Pages 1186-1211Publisher
WILEY
DOI: 10.1002/dneu.20934
Keywords
regeneration; transcription factors; Kruppel-like factors; axon growth
Categories
Funding
- National Eye Institute [EY020913, P30 EY014801]
- National Institute of Neurological Disorders and Stroke [NS061348, T32 NS07492, T32 NS007459]
- American Health Assistance Foundation
- Research to Prevent Blindness
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Understanding axon regenerative failure remains a major goal in neuroscience, and reversing this failure remains a major goal for clinical neurology. Although an inhibitory central nervous system environment clearly plays a role, focus on molecular pathways within neurons has begun to yield fruitful insights. Initial steps forward investigated the receptors and signaling pathways immediately downstream of environmental cues, but recent work has also shed light on transcriptional control mechanisms that regulate intrinsic axon growth ability, presumably through whole cassettes of gene target regulation. Here we will discuss transcription factors that regulate neurite growth in vitro and in vivo, including p53, SnoN, E47, cAMP-responsive element binding protein (CREB), signal transducer and activator of transcription 3 (STAT3), nuclear factor of activated T cell (NFAT), c-Jun activating transcription factor 3 (ATF3), sex determining region Ybox containing gene 11 (Sox11), nuclear factor kappa-light chain enhancer of activated B cells (NF kappa B), and Kruppel-like factors (KLFs). Revealing the similarities and differences among the functions of these transcription factors may further our understanding of the mechanisms of transcriptional regulation in axon growth and regeneration. (C) 2011 Wiley Periodicals, Inc. Develop Neurobiol 71: 1186-1211, 2011
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