Journal
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
Volume 56, Issue 6, Pages 516-521Publisher
WILEY
DOI: 10.1111/dmcn.12407
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Funding
- National Institute for Health Research
- National Institute for Health Research [CTF-01-12-02, CDF-2013-06-001, CL-2009-01-001] Funding Source: researchfish
- National Institutes of Health Research (NIHR) [CTF-01-12-02] Funding Source: National Institutes of Health Research (NIHR)
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Perinatal stroke is the most common cause of hemiplegic cerebral palsy. No standardized early intervention exists despite evidence for a critical time window for activity-dependent plasticity to mould corticospinal tract development in the first few years of life. Intervention during this unique period of plasticity could mitigate the consequences of perinatal stroke to an extent not possible with later intervention, by preserving the normal pattern of development of descending motor pathways. This article outlines the broad range of approaches currently under investigation. Despite significant progress in this area, improved early detection and outcome prediction remain important goals.
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