Journal
DEVELOPMENTAL DYNAMICS
Volume 243, Issue 2, Pages 315-323Publisher
WILEY
DOI: 10.1002/dvdy.24061
Keywords
p35; cdk5r1b; zebrafish; retinal development; cdk5; egr1; amacrine cells; smarca4
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Funding
- Knights Templar Eye Foundation
- International Retinal Research Foundation
- Hope for Vision
- Showalter Research Trust
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Background:Early growth response 1 (egr1) is a transcription factor (TF) for controlling the differentiation of Parvalbumin (Parv) -expressing amacrine cells (ACs) in zebrafish. However, the downstream factors of this process have not been identified. The purpose of this study was to investigate the role of p35, a neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) and a known in vitro target of egr1, in the differentiation of these ACs. Results: In the p35-knockdown retinas, Parv+ but not islet1+ ACs were specifically reduced. This phenotype was highly similar to that in the Egr1-knockdown retinas. Furthermore, p35 expression was reduced in the Egr1-knockdown retinas, particularly in the AC region; while egr1 was only modestly reduced in this region in the p35-knockdown retinas. Conclusions:p35 likely acts downstream of egr1 to control the differentiation of Parv+ ACs. Developmental Dynamics 243:315-323, 2014. (c) 2013 Wiley Periodicals, Inc.
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