Journal
DEVELOPMENTAL DYNAMICS
Volume 242, Issue 7, Pages 847-860Publisher
WILEY
DOI: 10.1002/dvdy.23976
Keywords
regeneration; axolotl; spinal cord injury (SCI); Nogo-A; Nogo receptor (NgR); myelin associated glycoprotein (MAG)
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Funding
- Department of Science and Technology, Government of India [SR/SO/AS-26/2004]
- Department of Biotechnology, Government of India [DBT/BT/PR13953/AAQ/03/523/2010]
- Kentucky Spinal Cord and Brain Injury Research Trust
- Department of Science and technology, Ministry of Science and Technology, Govt. of India
- Department of Biotechnology, Ministry of Science and Technology, Govt. of India
- Council of Scientific and Industrial Research, Govt. of India
- National Science Foundation [DBI-0951484]
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Background: The mammalian central nervous system is incapable of substantial axon regeneration after injury partially due to the presence of myelin-associated inhibitory molecules including Nogo-A and myelin associated glycoprotein (MAG). In contrast, axolotl salamanders are capable of considerable axon regrowth during spinal cord regeneration. Results: Here, we show that Nogo-A and MAG, and their receptor, Nogo receptor (NgR), are present in the axolotl genome and are broadly expressed in the central nervous system (CNS) during development, adulthood, and importantly, during regeneration. Furthermore, we show that Nogo-A and NgR are co-expressed in Sox2 positive neural progenitor cells. Conclusions: These expression patterns suggest myelin-associated proteins are permissive for neural development and regeneration in axolotls. Developmental Dynamics 242:847-860, 2013. (c) 2013 Wiley Periodicals, Inc.
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