Journal
DEVELOPMENTAL DYNAMICS
Volume 240, Issue 7, Pages 1826-1840Publisher
WILEY
DOI: 10.1002/dvdy.22669
Keywords
limb regeneration; urodele amphibian; gene expression microarray; regeneration epithelium
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Funding
- NIH [GM094944]
- ARO [W911NF-07-1-0252]
- [P20RR016470]
- [NSF-DBI-0443496]
- [NIH- NCRRR-24RR16344]
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Urodele amphibians are unique among adult vertebrates in their ability to regenerate missing limbs. The process of limb regeneration requires several key tissues including a regeneration-competent wound epidermis called the regeneration epithelium (RE). We used microarray analysis to profile gene expression of the RE in the axolotl, a Mexican salamander. A list of 125 genes and expressed sequence tags (ESTs) showed a >= 1.5-fold expression in the RE than in a wound epidermis covering a lateral cuff wound. A subset of the RE ESTs and genes were further characterized for expression level changes over the time-course of regeneration. This study provides the first large scale identification of specific gene expression in the RE. Developmental Dynamics 240:1826-1840, 2011. (C) 2011 Wiley-Liss, Inc.
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