Journal
DEVELOPMENTAL DYNAMICS
Volume 240, Issue 11, Pages 2466-2473Publisher
WILEY
DOI: 10.1002/dvdy.22748
Keywords
TMJ formation; glenoid fossa development; condyle; tissue interaction; Sox9
Categories
Funding
- NIH [DE17792]
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The mammalian temporomandibular joint (TMJ) develops from two distinct mesenchymal condensations that grow toward each other and ossify through different mechanisms, with the glenoid fossa undergoing intramembranous ossification while the condyle being endochondral in origin. In this study, we used various genetically modified mouse models to investigate tissue interaction between the condyle and glenoid fossa during TMJ formation in mice. We report that either absence or dislocation of the condyle results in an arrested glenoid fossa development. In both cases, glenoid fossa development was initiated, but failed to sustain, and became regressed subsequently. However, condyle development appears to be independent upon the presence of the forming glenoid fossa. In addition, we show that substitution of condyle by Meckel's cartilage is able to sustain glenoid fossa development. These observations suggest that proper signals from the developing condyle or Meckel's cartilage are required to sustain the glenoid fossa development. Developmental Dynamics 240: 2466-2473, 2011. (C) 2011 Wiley Periodicals, Inc.
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