Journal
DEVELOPMENTAL DYNAMICS
Volume 239, Issue 7, Pages 2041-2047Publisher
WILEY
DOI: 10.1002/dvdy.22338
Keywords
myelin; glia; differentiation; RNA profiling
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Funding
- National Multiple Sclerosis Society [RG3420]
- Vanderbilt Ingram Cancer Center [P30 CA68485]
- Vanderbilt Digestive Disease Research Center [DK058404, P30 DK58404]
- Vanderbilt Vision Center [P30 EY08126]
- Rocky Mountain Neurological Disorders [P30 NS048154]
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Myelination of central nervous system axons requires that oligodendrocytes extend multiple membrane processes that specifically recognize and wrap axons, which is followed by expression of proteins necessary for formation of myelin sheaths. To identify new genes that might be important for myelination, we used microarrays to analyze the expression profiles of cells sorted from transgenic zebrafish embryos and larvae under conditions that permitted or blocked oligodendrocyte development. Here, we describe eight genes that have not been previously implicated in oligodendrocyte development. Among the predicted functions of proteins encoded by these genes are lipid sensing, cell cell junction formation, cytoskeleton regulation, and intracellular signaling. The predicted functions raise the possibility that these genes are involved in multiple cellular events during oligodendrocyte differentiation and myelin formation. Developmental Dynamics 239:2041-2047, 2010. (C) 2010 Wiley-Liss, Inc.
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