Journal
DEVELOPMENTAL DYNAMICS
Volume 239, Issue 3, Pages 798-805Publisher
WILEY
DOI: 10.1002/dvdy.22207
Keywords
Serrate; inhibition; Notch, Delta; signaling
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Funding
- Wellcome Trust [PCAG/093]
- Fundacao para a Ciencia e Tecnologia [SFRH/BD/15213/2004]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/15213/2004] Funding Source: FCT
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The transmembrane proteins Delta and Serrate act as ligands for the signaling receptor Notch. In addition to this activating role, Delta and Serrate can also inhibit Notch signaling activity. This inhibitory effect is concentration-dependent and appears to be evolutionarily conserved. In characterizing the underlying cellular mechanisms of the ligand inhibitory effect, we can confirm that ligand-mediated inhibition of Notch signaling can occur as a cell autonomous process (cis-inhibition) and that ligand-mediated inhibition prevents a step in Notch signaling activation early enough to suppress Notch ectodomain shedding. Developmental Dynamics 239:798-805, 2010. (C) 2010 Wiley-Liss, Inc.
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