Journal
DEVELOPMENTAL DYNAMICS
Volume 239, Issue 5, Pages 1405-1412Publisher
WILEY
DOI: 10.1002/dvdy.22244
Keywords
DAF-16; FOXO; DAF-2; insulin; aging; longevity; C. elegans
Categories
Funding
- National Science Foundation
- NATIONAL INSTITUTE ON AGING [R01AG034446] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP2OD004402] Funding Source: NIH RePORTER
Ask authors/readers for more resources
In a remarkably conserved insulin signaling pathway that is well-known for its regulation of longevity in worms, flies, and mammals, the major C. elegans effector of this pathway, DAF-16/FOXO, also modulates many other physiological processes. This raises the question of how DAF-16/FOXO chooses the correct targets to achieve the appropriate response in a particular context. Here, we review current knowledge of tissue-specificity and interacting partners that modulate DAF-16/FOXO functional output. Developmental Dynamics 239:1405-1412, 2010. (C) 2010 Wiley-Liss, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available