Journal
DEVELOPMENTAL DYNAMICS
Volume 237, Issue 8, Pages 2147-2157Publisher
WILEY
DOI: 10.1002/dvdy.21621
Keywords
IA1; Xash1; Phox2a; Hand2; Hox11L2; tyrosine hydroxylase (TH); noradrenergic neuron; BMP; Notch; Xenopus
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The evolutionarily conserved IA1 (Insm1) gene is strongly expressed in the developing nervous system. Here, we show that IA1 is expressed during Xenopus laevis embryogenesis in neural plate primary neurons as well as in a population of uncharacterized anteroventral cells that form in front of the cement gland and that we identified as noradrenergic neurons. We also show that the formation of those anteroventral cells is dependent on BMPs and inhibited by Notch and that it is regulated by the transcription factors Xash1, Phox2, and Hand2. Finally, we provide functional evidence suggesting that IA1 may also play a role in their formation. Together, our results reveal that IA1 constitutes a novel player downstream of Xash1 in the formation of a previously unidentified population of Xenopus noradrenergic primary neurons.
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