Journal
DEVELOPMENTAL DYNAMICS
Volume 238, Issue 2, Pages 277-293Publisher
WILEY
DOI: 10.1002/dvdy.21757
Keywords
FGF receptor; development; C. elegans
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Funding
- European Union Marie Curie Early Stage Training Programme (MolFun)
- Medical Research Council
- Cancer and Polio Research Fund Laboratories
- North West Cancer Research Fund
- Medical Research Council [G0601549] Funding Source: researchfish
- MRC [G0601549] Funding Source: UKRI
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Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate a multitude of biological functions in embryonic development and in adult. A major question is bow does one family of growth factors and their receptors control such a variety of functions? Classically, specificity was thought to be imparted by alternative splicing of the FGFRs, resulting in isoforms that bind specifically to a subset of the FGFs, and by different saccharide sequences in the heparan sulfate proteoglycan (HSPG) co-receptor. A growing number of noncanonical co-receptors such as integrins and neural cell adhesion molecule (NCAM) are now recognized as imparting additional complexity to classic FGFR signaling. This review will discuss the noncanonical FGFR ligands and speculate on the possibility that they provide additional and alternative means to determining the functional specificity of FGFR signaling. We will also discuss how invertebrate models such as C. elegans may advance our understanding of noncanonical FGFR signaling. Developmental Dynamics 238:277-293, 2009. (c) 2008 Wiley-Liss, Inc.
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