Journal
DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS
Volume 18, Issue 1, Pages 68-74Publisher
WILEY
DOI: 10.1002/ddrr.1129
Keywords
fragile X syndrome; aging; neurodegeneration; FMRP
Categories
Funding
- National Institute of Health [HD036071, HD02274]
- Neurotherapeutic Research Institute (NTRI) [DE019583, DA024854]
- National Institute on Aging [AG032119, AG032115]
- National Institute of Mental Health [MH77554]
- National Center for Resources [UL1 RR024146]
- Health and Human Services Administration of Developmental Disabilities [90DD05969]
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Cognitive and behavioral correlates of molecular variations related to the FMR1 gene have been studied rather extensively, but research about the long-term outcome in individuals with fragile X spectrum disorders remains sparse. In this review, we present an overview of aging research and recent findings in regard to cellular and clinical manifestations of aging in fragile X syndrome, and the FMR1 premutation. (c) 2013 Wiley Periodicals, Inc. Dev Disabil Res Rev 2013;18:68-74.
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