Journal
DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS
Volume 16, Issue 3, Pages 239-247Publisher
WILEY
DOI: 10.1002/ddrr.116
Keywords
developmental disabilities; epilepsy; antiepileptic drugs; cognitive and behavioral adverse effects; pediatrics
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Children with developmental disabilities are at increased risk for epilepsy with a prevalence rate higher than the general population. Some of the more common developmental disorders in childhood and the features of epilepsy in these conditions are discussed. Specifically, autism, cerebral palsy, mental retardation, and attention deficit and hyperactivity disorder are reviewed. Ideal treatment for developmentally-disabled children with epilepsy entails maximal seizure control without any significant adverse effects from the anti-epileptic drugs and good quality of life. Antiepileptic drugs' cognitive and behavioral adverse effects tend to occur more frequently in these children. Careful selection of the appropriate medication and close monitoring for drug adverse effects is important. The specific adverse effects of the older and newer antiepileptic drugs are also reviewed. (C) 2010 Wiley-Liss, Inc. Dev Disabil Res Rev 2010;16:239-247.
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