Journal
DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS
Volume 16, Issue 2, Pages 106-113Publisher
WILEY
DOI: 10.1002/ddrr.102
Keywords
mitochondria; mitochondrial DNA; maternal inheritance; intergenomic signaling
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Funding
- National Institute of Health [HD 32062]
- Marriott Mitochondrial Disorder Clinical Research Fund (MMDCRF)
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [P01HD032062] Funding Source: NIH RePORTER
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In this review, we trace the origins and follow the development of mitochondrial medicine from the premolecular era (1962-1988) based on clinical clues, muscle morphology, and biochemistry into the molecular era that started in 1988 and is still advancing at a brisk pace. We have tried to stress conceptual advances, such as endosymbiosis, uniparental inheritance, intergenomic signaling and its defects, and mitochondria! dynamics. We hope that this historical review also provides an update on mitochondrial medicine, although we fully realize that the speed of progress in this area makes any such endeavor akin to writing on water. (C) 2010 Wiley-Liss, Inc. Dev Disabil Res Rev 2010;16:106-113.
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