Journal
DEVELOPMENTAL CELL
Volume 30, Issue 1, Pages 36-47Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2014.05.020
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Funding
- FI PhD fellowship from the Generalitat de Catalunya (GC)
- DFG [BE1-00924, SFB873]
- Spanish Ministry de Economy and Competitiveness [FIS2012-37655-C02-02]
- GC [2009SGR14]
- Laboratoire d'Excellence (LABEX) TULIP [ANR-10-LABX-41]
- Juan de la Cierva post-doctoral contract from the Spanish Ministry of Science
- HFSP short-term fellowship
- NSF Arabidopsis grant
- Spanish Ministry of Innovation and Science [BIO2010/007]
- Marie-Curie Initial Training Network BRAVISSIMO [PITN-GA-2008-215118]
- [FPU-AP2009-3736]
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The quiescent center (QC) maintains the activity of the surrounding stem cells within the root stem cell niche, yet specific molecular players sustaining the low rate of QC cell division remain poorly understood. Here, we identified a R2R3-MYB transcription factor, BRAVO (BRASSINOSTEROIDS AT VASCULAR AND ORGANIZING CENTER), acting as a cell-specific repressor of QC divisions in the primary root of Arabidopsis. Ectopic BRAVO expression restricts overall root growth and ceases root regeneration upon damage of the stem cells, demonstrating the role of BRAVO in counteracting Brassinosteroid (BR)-mediated cell division in the QC cells. Interestingly, BR-regulated transcription factor BES1 (BRI1-EMS SUPRESSOR 1) directly represses and physically interacts with BRAVO in vivo, creating a switch that modulates QC divisions at the root stem cell niche. Together, our results define a mechanism for BR-mediated regulation of stem cell quiescence in plants.
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