Journal
DEVELOPMENTAL CELL
Volume 30, Issue 1, Pages 86-94Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2014.06.006
Keywords
-
Categories
Funding
- State of Lower Saxony, Hannover, Germany [ZN2444]
- project P11 [SFB 944]
- Hans-Muhlenhoff foundation
- ECHO [700.59.003]
- ALW Open Program [821.02.017, 822.02.014]
- DFG-NWO cooperation [DN82-303]
- ZonMW VICI [016.130.606]
- Deutsche Forschungsgemeinschaft [SFB 746]
- Excellence initiative of the German Federal Government [EXC 294 BIOSS]
- Excellence initiative of the German State Government [EXC 294 BIOSS]
Ask authors/readers for more resources
Emerging evidence suggests that contact sites between different organelles form central hubs in the coordination of cellular physiology. Although recent work has emphasized the crucial role of the endoplasmic reticulum in interorganellar crosstalk, the cooperative behavior of other organelles is largely unexplored. Here, we identify a contact site named vCLAMP (vacuole and mitochondria patch) that integrates mitochondria with the lysosome-like vacuole and thus the endocytic pathway. vCLAMPs depend on the vacuolar HOPS tethering complex subunit Vps39/Vam6 and the Rab GTPase Ypt7, which also participate in membrane fusion at the vacuole. Intriguingly, vCLAMPs are located proximal to the ER-mitochondria encounter structure (ERMES) complexes, and an increase in vCLAMPs can rescue the growth defect of ERMES mutants. Importantly, the persistence of vCLAMPs is regulated by phosphorylation of Vps39 and is strongly reduced during respiratory growth. The identification of this organelle contact site reveals a physical and metabolic interconnection between the endocytic pathway and mitochondria.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available