Journal
DEVELOPMENTAL CELL
Volume 30, Issue 1, Pages 95-102Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2014.06.007
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Funding
- European Research Council Starting Grant [260395]
- Weizmann Institute
- EMBO Young Investigator Program
- Israel Ministry of Science
- Marie Curie International Reintegration Grant of the European Union [239224]
- Israel Science Foundation
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Cellular life depends on continuous transport of lipids and small molecules between mitochondria and the endomembrane system. Recently, endoplasmic reticulum-mitochondrial encounter structure (ERMES) was identified as an important yet nonessential contact for such transport. Using a high-content screen in yeast, we found a contact site, marked by Vam6/Vps39, between vacuoles (the yeast lysosomal compartment) and mitochondria, named vCLAMP (vacuole and mitochondria patch). vCLAMP is enriched with ion and amino-acid transporters and has a role in lipid relay between the endomembrane system and mitochondria. Critically, we show that mitochondria are dependent on having one of two contact sites, ERMES or vCLAMP. The absence of one causes expansion of the other, and elimination of both is lethal. Identification of vCLAMP adds to our ability to understand the complexity of interorganellar crosstalk.
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