Journal
DEVELOPMENTAL CELL
Volume 24, Issue 5, Pages 447-458Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2013.02.012
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Funding
- Israel Science Foundation
- National Institutes of Health Cell Migration Consortium [U546M64346]
- National Institutes of Health Nanomedicine Development Center Network [PN2 EY016586]
- European Union's Seventh Framework Programme [258068]
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Integrin-mediated cell adhesions to the extracellular matrix (ECM) contribute to tissue morphogenesis and coherence and provide cells with vital environmental cues. These apparently static structures display remarkable plasticity and dynamic properties: they exist in multiple, interconvertible forms that are constantly remodeled in response to changes in ECM properties, cytoskeletal organization, cell migration, and signaling processes. Thus, integrin-mediated environmental sensing enables cells to adapt to chemical and physical properties of the surrounding matrix by modulating their proliferation, differentiation, and survival. This intriguing interplay between the apparently robust structure of matrix adhesions and their highly dynamic properties is the focus of this article.
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