Journal
DEVELOPMENTAL CELL
Volume 25, Issue 6, Pages 599-609Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2013.05.013
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Funding
- David Phillips Fellowship from the BBSRC
- Research Prize from the Lister Institute
- International Reintegration Grant
- EMBO Long-Term Fellowship
- Wellcome Trust Programme Grant
- Biotechnology and Biological Sciences Research Council [BB/F023243/1] Funding Source: researchfish
- Medical Research Council [G0601744, MR/K017047/1B] Funding Source: researchfish
- BBSRC [BB/F023243/1] Funding Source: UKRI
- MRC [G0601744] Funding Source: UKRI
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The number of myelin sheaths made by individual oligodendrocytes regulates the extent of myelination, which profoundly affects central nervous system function. It remains unknown when, during their life, individual oligodendrocytes can regulate myelin sheath number in vivo. We show, using live imaging in zebrafish, that oligodendrocytes make new myelin sheaths during a period of just 5 hr, with regulation of sheath number after this time limited to occasional retractions. We also show that activation and reduction of Fyn kinase in oligodendrocytes increases and decreases sheath number per cell, respectively. Interestingly, these oligodendrocytes also generate their new myelin sheaths within the same period, despite having vastly different extents of myelination. Our data demonstrate a restricted time window relative to the lifetime of the individual oligodendrocyte, during which myelin sheath formation occurs and the number of sheaths is determined.
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