4.7 Article

Snf2I Regulates Foxg1-Dependent Progenitor Cell Expansion in the Developing Brain

Journal

DEVELOPMENTAL CELL
Volume 22, Issue 4, Pages 871-878

Publisher

CELL PRESS
DOI: 10.1016/j.devcel.2012.01.020

Keywords

-

Funding

  1. HSFCSR
  2. OGSST
  3. Ontario Graduate Scholarship
  4. CIHR

Ask authors/readers for more resources

Balancing progenitor cell self-renewal and differentiation is essential for brain development and is regulated by the activity of chromatin remodeling complexes. Nevertheless, linking chromatin changes to specific pathways that control cortical histogenesis remains a challenge. Here we identify a genetic interaction between the chromatin remodeler Snf2I and Foxg1, a key regulator of neurogenesis. Snf2I mutant mice exhibit forebrain hypercellularity arising from increased Foxg1 expression, increased progenitor cell expansion, and delayed differentiation. We demonstrate that Snf2I binds to the Foxg1 locus at midneurogenesis and that the phenotype is rescued by reducing Foxg1 dosage, thus revealing that Snf2I and Foxg1 function antagonistically to regulate brain size.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available