Journal
DEVELOPMENTAL CELL
Volume 23, Issue 5, Pages 921-923Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2012.10.025
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Funding
- NHLBI NIH HHS [R01 HL052173] Funding Source: Medline
- NIDDK NIH HHS [R37 DK042394, R01 DK088227] Funding Source: Medline
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IRE1 alpha, the most conserved transducer of the unfolded protein response, plays critical roles in many biological processes and cell fate decisions. Reporting in Science, Upton et al. (2012) broadened our understanding of IRE1 alpha as a cell-death executioner, showing that upon ER stress, IRE1 alpha degrades microRNAs to promote translation of caspase-2.
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