Journal
DEVELOPMENTAL CELL
Volume 21, Issue 1, Pages 102-119Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2011.06.012
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Funding
- HFSP
- ANR [BLAN07-3-207540]
- CNRS
- INSERM [R08221JS]
- ERC [CePoDro 209718]
- Curie Institute
- Fondation pour la Recherche Medicale (FRM)
- ENS
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The orientation of the mitotic spindle has been proposed to control cell fate choices, tissue architecture, and tissue morphogenesis. Here, we review the mechanisms regulating the orientation of the axis of division and cell fate choices in classical models of asymmetric cell division. We then discuss the mechanisms of mitotic spindle orientation in symmetric cell divisions and its possible implications in tissue morphogenesis. Many recent studies show that future advances in the field of mitotic spindle orientation will arise from combinations of physical perturbation and modeling with classical genetics and developmental biology approaches.
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