Journal
DEVELOPMENTAL CELL
Volume 21, Issue 3, Pages 410-419Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2011.07.018
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Funding
- NIH [GM052932]
- [5F32GM090674]
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The spindle directs chromosome partitioning in eukaryotes and, for the last three decades, has been considered primarily a structure based on microtubules, microtubule motors, and other microtubule binding proteins. However, a surprisingly large body of both old and new studies suggests roles for actin filaments (F-actin) and myosins (F-actin-based motor proteins) in spindle assembly and function. Here we review these data and conclude that in several cases the evidence for the participation of F-actin and myosins in spindle function is very strong, and in the situations where it is less strong, there is nevertheless enough evidence to warrant further investigation.
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