Journal
DEVELOPMENTAL CELL
Volume 19, Issue 1, Pages 78-89Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2010.06.006
Keywords
-
Categories
Funding
- CoMPLEX
- Cancer Research UK
- University College London
- Royal Society
- King's College London
- M G
- Cancer Research UK [9786] Funding Source: researchfish
- Medical Research Council [MC_CF12266] Funding Source: researchfish
Ask authors/readers for more resources
The organization of bristles on the Drosophila notum has long served as a popular model of robust tissue patterning. During this process, membrane-tethered Delta activates intracellular Notch signaling in neighboring epithelial cells, which inhibits Delta expression. This induces lateral inhibition, yielding a pattern in which each Delta-expressing mechanosensory organ precursor cell in the epithelium is surrounded on all sides by cells with active Notch signaling. Here, we show that conventional models of Delta-Notch signaling cannot account for bristle spacing or the gradual refinement of this pattern. Instead, the pattern refinement we observe using live imaging is dependent upon dynamic, basal actin-based filopodia and can be quantitatively reproduced by simulations of lateral inhibition incorporating Delta-Notch signaling by transient filopodial contacts between nonneighboring cells. Significantly, the intermittent signaling induced by these filopodial dynamics generates a type of structured noise that is uniquely suited to the generation of well-ordered, tissue-wide epithelial patterns.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available