Journal
DEVELOPMENTAL CELL
Volume 19, Issue 5, Pages 698-711Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2010.10.005
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- ICREA Funding Source: Custom
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Appropriate patterns of DNA methylation and histone modifications are required to assure cell identity, and their deregulation can contribute to human diseases, such as cancer Our aim here is to provide an overview of how epigenetic factors, including genomic DNA methylation, histone modifications, and microRNA regulation, contribute to normal development, paying special attention to their role in regulating tissue-specific genes In addition, we summarize how these epigenetic patterns go awry during human cancer development The possibility of resetting the abnormal cancer epigenome by applying pharmacological or genetic strategies is also discussed
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