Journal
DEVELOPMENTAL CELL
Volume 19, Issue 6, Pages 797-806Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2010.11.011
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Accurate segregation of chromosomes during cell division is accomplished through the assembly of a bipolar microtubule-based structure called the mitotic spindle. Work over the past two decades has identified a core regulator of spindle bipolarity, the microtubule motor protein kinesin-5. However, an increasing body of evidence has emerged demonstrating that kinesin-5-independent mechanisms driving bipolar spindle assembly exist as well. Here, we discuss different pathways that promote initial centrosome separation and bipolar spindle assembly.
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