Journal
DEVELOPMENTAL CELL
Volume 17, Issue 4, Pages 494-504Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2009.08.008
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Funding
- Wellcome Trust [WT075336AIA]
- BBSRC [BB/C504200/1]
- EPA Cephalosporin Trust [CF077]
- Royal Society
- Daimler-Benz Foundation
- Algerian Ministry of Higher Education and Scientific Research
- BBSRC
- Marie Curie Fellowships program
- Biotechnology and Biological Sciences Research Council [BB/C504200/1] Funding Source: researchfish
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Understanding the mechanisms that coordinate the orientation of cell division planes during embryogenesis and morphogenesis is a fundamental problem in developmental biology. Here we show that the orphan receptor lat-1, a homolog of vertebrate latrophilins, plays an essential role in the establishment of tissue polarity in the C. elegans embryo. We provide evidence that lat-1 is required for the alignment of cell division planes to the anterior-posterior axis and acts in parallel to known polarity and morphogenesis signals. lat-1 is a member of the Adhesion-GPCR protein family and is structurally related to flamingo/CELSR, an essential component of the planar cell polarity pathway. We dissect the molecular requirements of lat-1 signaling and implicate lat-1 in an anterior-posterior tissue polarity pathway in the pre-morphogenesis stage of C. elegans development.
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