Journal
DEVELOPMENTAL CELL
Volume 15, Issue 1, Pages 163-169Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2008.05.016
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Funding
- NINDS NIH HHS [R01 NS051786, R01 NS051786-01A2, R01 NS051786-03, R01-NS28695, R01 NS028695, R01-NS051786, R01 NS051786-02, R01 NS028695-18, R01 NS028695-17] Funding Source: Medline
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The cell biological processes underlying axon growth and guidance are still not well understood. An outstanding question is how a new segment of the axon shaft is formed in the wake of neuronal growth cone advance. For this to occur, the highly dynamic, splayed-out microtubule (MT) arrays characteristic of the growth cone must be consolidated (bundled together) to form the core of the axon shaft. MT-associated proteins stabilize bundled MTs, but how individual MTs are brought together for initial bundling is unknown. Here, we show that laterally moving actin arcs, which are myosin II-driven contractile structures, interact with growing MTs and transport them from the sides of the growth cone into the central domain. Upon Myosin 11 inhibition, the movement of actin filaments and MTs immediately stopped and MTs unbundled. Thus, Myosin II-dependent compressive force is necessary for normal MT bundling in the growth cone neck.
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