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Hedgehog Signaling in Development and Cancer

Journal

DEVELOPMENTAL CELL
Volume 15, Issue 6, Pages 801-812

Publisher

CELL PRESS
DOI: 10.1016/j.devcel.2008.11.010

Keywords

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Funding

  1. NIH
  2. Leukemia and Lymphoma Society Scholar Program
  3. Welch Foundation
  4. National Cancer Institute of Canada

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The Hedgehog (Hh) family of secreted proteins governs a wide variety of processes during embryonic development and adult tissue homeostasis. Here we review the current understanding of the molecular and cellular basis of Hh morphogen gradient formation and signal transduction, and the multifaceted roles of Hh signaling in development and tumorigenesis. We discuss how the Hh pathway has diverged during evolution and how it integrates with other signaling pathways to control cell growth and patterning.

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