Journal
DEVELOPMENTAL CELL
Volume 15, Issue 6, Pages 795-796Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2008.11.013
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Endoplasmic reticulum (ER) stress and activation of the unfolded protein response have been linked to many human disorders, including obesity, type 2 diabetes, and cancer. In this issue of Developmental Cell, Rutkowski et al. (2008) show that unresolved ER stress contributes to metabolic dysfunction and hepatic steatosis.
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