Journal
DEVELOPMENTAL CELL
Volume 15, Issue 3, Pages 344-357Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2008.08.012
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Funding
- Fondazione Telethon
- Compagnia di San Paolo
- AIRC
- Italian Ministry of University and Research (MUR)
- Italian Ministry of Health
- National Institutes of Health
- American Cancer Society
- Howard Hughes Medical Institute
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Autophagy is important for the degradation of bulk cytoplasm, long-lived proteins, and entire organelles. In lower eukaryotes, autophagy functions as a cell death mechanism or as a stress response during development. However, autophagy's significance in vertebrate development, and the role (if any) of vertebrate-specific factors in its regulation, remains unexplained. Through careful analysis of the current autophagy gene mutant mouse models, we propose that in mammals, autophagy may be involved in specific cytosolic rearrangements needed for proliferation, death, and differentiation during embryogenesis and postnatal development. Thus, autophagy is a process of cytosolic renovation, crucial in cell fate decisions.
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