Journal
DEVELOPMENTAL CELL
Volume 14, Issue 1, Pages 1-3Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2007.12.017
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An article by Li and colleagues (in this issue of Developmental Cell) shows that the atypical E2Fs, E2F7 and E2F8, are critical for mouse development. One of the important functions of these family members stems from a negative feedback loop in which E2F7 and E2F8 limit the expression of E2F1 and prevent E2F1-dependent apoptosis.
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