Journal
DEVELOPMENTAL CELL
Volume 15, Issue 5, Pages 641-642Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2008.10.009
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Funding
- NIAID NIH HHS [R37 AI042999, R01 AI042999] Funding Source: Medline
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Recent genome-wide association studies have linked polymorphisms in two atophagy genes, Atg16L1 and IRGM, with Crohn's Disease. Now, experiments with Atg16L1 transgenic mice indicate multiple roles for autophagy in inflammatory bowel disease via effects on Paneth cells, a runaway inflammasome, and the proinflammatory cytokine IL-1 beta.
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