Journal
DEVELOPMENTAL BIOLOGY
Volume 392, Issue 1, Pages 1-14Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2014.05.004
Keywords
Zebrafish; Lateral line; Neuromast; Organ growth; Scale; Bone remodeling
Categories
Funding
- National BioResource Project
- Japan Society for the Promotion of Science (JSPS) KAKENHI [25440118]
- Grants-in-Aid for Scientific Research [25440118, 23241063] Funding Source: KAKEN
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The lateral line system of teleost fish is composed of mechanosensory receptors (neuromasts), comprising superficial receptors and others embedded in canals running under the skin. Canal diameter and size of the canal neuromasts are correlated with increasing body size, thus providing a very simple system to investigate mechanisms underlying the coordination between organ growth and body size. Here, we examine the development of the trunk lateral line canal system in zebrafish. We demonstrated that trunk canals originate from scales through a bone remodeling process, which we suggest is essential for the normal growth of canals and canal neuromasts. Moreover, we found that lateral line cells are required for the formation of canals, suggesting the existence of mutual interactions between the sensory system and surrounding connective tissues. (C) 2014 Elsevier Inc. All rights reserved.
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