Journal
DEVELOPMENTAL BIOLOGY
Volume 374, Issue 1, Pages 185-197Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2012.11.014
Keywords
Fgf8; Nasal capsule; Optic capsule; Mouse; Ectoderm; Midface; Craniofacial; Trabecular basal plate; FEZ
Categories
Funding
- Royal Society
- Dental Institute of King's College London
- Friends of Guy's Hospital
- Marie Curie Early Training Fellowships [MEST-CT-2004-504025]
- HFSP Long Term Fellowship [LT 01061/2007-L]
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Craniofacial development requires an exquisitely timed and positioned cross-talk between the embryonic cephalic epithelia and mesenchyme. This cross-talk underlies the precise translation of patterning processes and information into distinct, appropriate skeletal morphologies. The molecular and cellular dialogue includes communication via secreted signaling molecules, including Fe, and effectors of their interpretation. Herein, we use genetic attenuation of Fe in mice and perform gain-of-function mouse-chick chimeric experiments to demonstrate that significant character states of the frontonasal and optic skeletons are dependent on Fgf8. Notably, we show that the normal orientation and polarity of the nasal capsules and their developing primordia are dependent on Fe. We further demonstrate that Fgf8 is required for midfacial integration, and provide evidence for a role for Fgf8 in optic capsular development. Taken together, our data highlight Fgf8 signaling in craniofacial development as a plausible target for evolutionary selective pressures. (c) 2012 Elsevier Inc. All rights reserved.
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