Journal
DEVELOPMENTAL BIOLOGY
Volume 349, Issue 1, Pages 1-19Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2010.09.008
Keywords
Semaphorin; Sema; Plexin; Plxn; PlexinD1; PlxnD1; Signaling; Review; Blood vessel; Angiogenesis; Nervous system; Axon guidance; Tumor; Cancer; Immune
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Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL092263] Funding Source: NIH RePORTER
- NHLBI NIH HHS [R01 HL092263-01A1, R01 HL092263, R01 HL092263-01A1S1] Funding Source: Medline
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Plexins are a family of single-pass transmembrane proteins that serve as cell surface receptors for Semaphorins during the embryonic development of animals. Semaphorin-Plexin signaling is critical for many cellular aspects of organogenesis, including cell migration, proliferation and survival. Until recently, little was known about the function of PlexinD1, the sole member of the vertebrate-specific PlexinD (PlxnD1) subfamily. Here we review novel findings about PlxnD1's roles in the development of the cardiovascular, nervous and immune systems and salivary gland branching morphogenesis and discuss new insights concerning the molecular mechanisms of PlxnD1 activity. (C) 2010 Elsevier Inc. All rights reserved.
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