Journal
DEVELOPMENTAL BIOLOGY
Volume 358, Issue 1, Pages 1-8Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2011.06.043
Keywords
Posttranslational modifications; Arginylation; Arginyl tRNA protein transferase; Arginyltransferase; Regulation of development; Angiogenesis; Ubiquitin; Proteasome
Categories
Funding
- NIH [5R01HL084419]
- W.W. Smith Charitable Trust
- Philip Morris Research Management Group
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Posttranslational modifications constitute a major field of emerging biological significance as mounting evidence demonstrates their key role in multiple physiological processes. Following in the footsteps of protein phosphorylation studies, new modifications are being shown to regulate protein properties and functions in vivo. Among such modifications, an important role belongs to protein arginylation - posttranslational tRN-Amediated addition of arginine, to proteins by arginyltransferase, ATE1. Recent studies show that arginylation is essential for embryogenesis in many organisms and that it regulates such important processes as heart development, angiogenesis, and tissue morphogenesis in mammals. This review summarizes the key data in the protein arginylation field since its original discovery to date. (C) 2011 Elsevier Inc. All rights reserved.
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