Journal
DEVELOPMENTAL BIOLOGY
Volume 340, Issue 2, Pages 504-517Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2010.02.008
Keywords
Tenectin; Integrin; Ecdysone; Metamorphosis; Adhesion; Looping morphogenesis; Left-right asymmetry
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Funding
- Centre National de la Recherche Scientifique (CNRS)
- University of Burgundy
- French ministry of Research and Education
- FRM (Medical Research Foundation)
- ARC (Cancer Research Association)
- NIH [R01GM42474]
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Morphogenesis of the adult structures of holometabolous insects is regulated by ecdysteroids and juvenile hormones and involves cell-cell interactions mediated in part by the cell surface integrin receptors and their extracellular matrix (ECM) ligands. These adhesion molecules and their regulation by hormones are not well characterized. We describe the gene structure of a newly described ECM molecule, tenectin, and demonstrate that it is a hormonally regulated ECM protein required for proper morphogenesis of the adult wing and male genitalia. Tenectin's function as a new ligand of the PS2 integrins is demonstrated by both genetic interactions in the fly and by cell spreading and cell adhesion assays in cultured cells. Its interaction with the PS2 integrins is dependent on RGD and RGD-like motifs. Tenectin's function in looping morphogenesis in the development of the male genitalia led to experiments that demonstrate a role for PS integrins in the execution of left-right asymmetry. (C) 2010 Elsevier Inc. All rights reserved.
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