Journal
DEVELOPMENTAL BIOLOGY
Volume 332, Issue 2, Pages 309-324Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2009.05.575
Keywords
Stellate cell; Basket cell; Inhibitory interneurons; Neuronal cell migration; Cerebellum; Early postnatal mice; Time-lapse imaging; Brain slices
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Funding
- National Multiple Sclerosis Society [PP1450]
- National Institute of Environmental Health Sciences [R01 ES015612]
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In the adult cerebellum, basket/stellate cells are scattered throughout the ML, but little is known about the process underlying the cell dispersion. To determine the allocation of stellate/basket cells within the ML we, examined their Migration in the early postnatal mouse cerebellum. We found that after entering the ML, basket/stellate cells sequentially exhibit four distinct phases of migration. First, the cells migrated radially from the bottom to the top while exhibiting saltatory movement with a single leading process (Phase I). Second, the cells turned at the top and migrated tangentially in a rostro-caudal direction, with an occasional reversal of the direction of migration (Phase II). Third, the cells turned and migrated radially within the ML at a significantly reduced speed while repeatedly extending and withdrawing the leading processes (Phase III). Fourth, the cells turned at the middle and migrated tangentially at their slowest speed, while extending several dendrite-like processes after having completely withdrawn the leading process (Phase IV), Finally, the cells stopped and completed their migration. These results suggest that the dispersion of basket/stellate cells in the ML is controlled by the orchestrated activity of external guidance cues cell-cell contact and, intrinsic programs in a position- and time-dependent manner. (C) 2009 Elsevier Inc. All rights reserved.
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