Journal
DEVELOPMENTAL BIOLOGY
Volume 320, Issue 1, Pages 1-11Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2008.04.041
Keywords
reactive oxygen species; superoxide; hydrogen peroxide; oxidative stress; antioxidants; redox regulation; signal transduction; proliferation; differentiation; apoptosis; pogrammed cell death; morphogenesis; development
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Oxidative stress is considered causal of aging and pathological cell death, however, very little is known about its function in the natural processes that support the formation of an organism. It is generally thought that Cells most continuously protect themselves from the possible damage caused by reactive oxygen species (ROS) (passive ROS function). However, presently, ROS are recognized as physiologically relevant molecules that mediate cell responses to a variety of stimuli, and the activities of several molecules, some developmentally relevant, are directly or indirectly regulated by oxidative stress (active ROS function). Here we review recent data that are suggestive of specific ROS functions during development of animals, Particularly mammals. (C) 2008 Elsevier Inc. All rights reserved.
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